| Function | Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation. |
| Protein Name | Ankyrin Repeat - Sam And Basic Leucine Zipper Domain-Containing Protein 1Ankyrin-Like Protein 1Germ Cell-Specific Ankyrin - Sam And Basic Leucine Zipper Domain-Containing Protein |
| Database Links | Reactome: R-HSA-5601884 |
| Cellular Localisation | CytoplasmComponent Of The Meiotic NuageAlso Named P GranuleA Germ-Cell-Specific Organelle Required To Repress Transposon Activity During MeiosisSpecifically Localizes To Pi-BodiesA Subset Of The Nuage Which Contains Primary Pirnas |
| Alternative Protein Names | Ankyrin Repeat - Sam And Basic Leucine Zipper Domain-Containing Protein 1 proteinAnkyrin-Like Protein 1 proteinGerm Cell-Specific Ankyrin - Sam And Basic Leucine Zipper Domain-Containing Protein proteinASZ1 proteinALP1 proteinANKL1 proteinC7orf7 proteinGASZ protein |
Information sourced from Uniprot.org
