| Post Translational Modifications | Ubiquitinated by TRIP12, leading to its subsequent degradation following binding of N(6)-methyladenine methylated DNA (6mA). |
| Function | Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG). Acts as a coactivator of RARA and RXRA through association with NCOA1. Acts as a corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Acts as a sensor of N(6)-methyladenine methylation on DNA (6mA): recognizes and binds 6mA DNA, leading to its ubiquitination and degradation by TRIP12, thereby inactivating the PR-DUB complex and regulating Polycomb silencing. The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability. ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex. The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes. ASXL1 and ASXL2 are important for BAP1 protein stability. Together with BAP1, negatively regulates epithelial-mesenchymal transition (EMT) of trophoblast stem cells during placental development by regulating genes involved in epithelial cell integrity, cell adhesion and cytoskeletal organization. |
| Protein Name | Polycomb Group Protein Asxl1Additional Sex Combs-Like Protein 1 |
| Database Links | Reactome: R-HSA-5689603 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Polycomb Group Protein Asxl1 proteinAdditional Sex Combs-Like Protein 1 proteinASXL1 proteinKIAA0978 protein |
Information sourced from Uniprot.org
