Human ARL3 protein (Recombinant) (N-His) (STJP007562)

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STJP007562
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ARL3-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: ARL3
Gene ID: 403
Uniprot ID: ARL3_HUMAN
Immunogen Region: Met1-Lys182
Immunogen: Homo sapiens (Human)
Function Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium. Required for PKD1:PKD2 complex targeting from the trans-Golgi network to the cilium.
Protein Name Adp-Ribosylation Factor-Like Protein 3
Database Links Reactome: R-HSA-5624138
Cellular Localisation Golgi Apparatus Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Cytoplasm
Cytoskeleton
Spindle
Nucleus
Microtubule Organizing Center
Centrosome
Cell Projection
Cilium
Detected Predominantly In The Photoreceptor Connecting Cilium
Present On The Mitotic Spindle
Centrosome-Associated Throughout The Cell Cycle
Not Detected To Interphase Microtubules
Alternative Protein Names Adp-Ribosylation Factor-Like Protein 3 protein
ARL3 protein
ARFL3 protein

Information sourced from Uniprot.org