Human ARHGEF1 protein (Recombinant) (N-His) (STJP008170)

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STJP008170
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ARHGEF1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: ARHGEF1
Gene ID: 9138
Uniprot ID: ARHG1_HUMAN
Immunogen Region: Ser39-Gly230
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated by PKCA. Angiotensin-2 induced Tyr-738 phosphorylation is mediated by JAK2.
Function Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as a GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.
Protein Name Rho Guanine Nucleotide Exchange Factor 1
115 Kda Guanine Nucleotide Exchange Factor
P115-Rhogef
P115rhogef
Sub1.5
Database Links Reactome: R-HSA-193648
Reactome: R-HSA-416482
Reactome: R-HSA-8980692
Reactome: R-HSA-9013026
Reactome: R-HSA-9013106
Cellular Localisation Cytoplasm
Membrane
Translocated To The Membrane By Activated Gna13 Or Lpa Stimulation
Alternative Protein Names Rho Guanine Nucleotide Exchange Factor 1 protein
115 Kda Guanine Nucleotide Exchange Factor protein
P115-Rhogef protein
P115rhogef protein
Sub1.5 protein
ARHGEF1 protein

Information sourced from Uniprot.org

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