| Short Description : | Recombinant-Human ARHGAP21-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications: | ELISA/Immunogen/SDS-PAGE/WB |
| Host: | E.coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Dilution Range: | Reconstitute in sterile water for a stock solution. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin: | Please contact us for further information. |
| Gene Symbol: | ARHGAP21 |
| Gene ID: | 57584 |
| Uniprot ID: | RHG21_HUMAN |
| Immunogen: | Homo sapiens (Human) |
| Immunogen Region: | Gly1143-Ala1344 |
| Post Translational Modifications | Sumoylated with SUMO2 and SUMO3 in proliferating lymphocytes. |
| Function | Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions. |
| Protein Name | Rho Gtpase-Activating Protein 21Rho Gtpase-Activating Protein 10Rho-Type Gtpase-Activating Protein 21 |
| Database Links | Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013405Reactome: R-HSA-9013406Reactome: R-HSA-9013408Reactome: R-HSA-9013409Reactome: R-HSA-9013423Reactome: R-HSA-9035034Reactome: R-HSA-9696264 |
| Cellular Localisation | Golgi Apparatus MembranePeripheral Membrane ProteinCell JunctionCytoplasmic Vesicle MembraneCytoplasmCytoskeletonLocalization To The Golgi Is Dependent On Interaction With Gtp-Bound Arf1 |
| Alternative Protein Names | Rho Gtpase-Activating Protein 21 proteinRho Gtpase-Activating Protein 10 proteinRho-Type Gtpase-Activating Protein 21 proteinARHGAP21 proteinARHGAP10 proteinKIAA1424 protein |
Information sourced from Uniprot.org