Human ARFIP1 protein (Recombinant) (N-His) (STJP015758)

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STJP015758
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Host: E.coli
Applications: ELISA/Immunogen/SDS-PAGE/WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ARFIP1-N-His protein was developed from e.coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: Please contact us for further information.
Gene Symbol: ARFIP1
Gene ID: 27236
Uniprot ID: ARFP1_HUMAN
Immunogen Region: Ile117-Gln373
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated by PRKD1.phosphorylation delocalizes ARFIP1 from the Golgi and disrupts its ability to inhibit the activity of ADP-ribosylation factor, an important component of the vesicle scission machinery.
Function Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network. Mechanistically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold. Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs. In turn, ARFs induce fission. Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells.
Protein Name Arfaptin-1
Adp-Ribosylation Factor-Interacting Protein 1
Database Links
Cellular Localisation Golgi Apparatus
Trans-Golgi Network Membrane
Alternative Protein Names Arfaptin-1 protein
Adp-Ribosylation Factor-Interacting Protein 1 protein
ARFIP1 protein

Information sourced from Uniprot.org

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