Human ARFIP1 protein (Recombinant) (His-Tag) (STJP018917)

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STJP018917
€161.40 - €886.20
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ARFIP1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in phosphate-Buffered Saline (pH 7.4) 30% Glycerol, 1mM DTT
Concentration: 0.25 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: ARFIP1
Gene ID: 27236
Uniprot ID: ARFP1_HUMAN
Immunogen Region: 1-341aa
Accession Number: NP_055262
Immunogen: Human
Immunogen Sequence: MGSSHHHHHH SSGLVPRGSH MGSMAQESPK NSAAEIPVTS NGEVDDSREH SFNRDLKHSL PSGLGLSETQ ITSHGFDNTK EGVIEAGAFQ GGQRTQTKSG PVILADEIKN PAMEKLELVR KWSLNTYKCT RQIISEKLGR GSRTVDLELE AQIDILRDNK KKYENILKLA QTLSTQLFQM VHTQRQLGDA FADLSLKSLE LHEEFGYNAD TQKLLAKNGE TLLGAINF
Tissue Specificity Ubiquitously expressed. Higher levels in liver, pancreas, placenta, skeletal muscle and heart.
Post Translational Modifications Phosphorylated by PRKD1.phosphorylation delocalizes ARFIP1 from the Golgi and disrupts its ability to inhibit the activity of ADP-ribosylation factor, an important component of the vesicle scission machinery.
Function Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network. Mechanistically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold. Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs. In turn, ARFs induce fission. Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells.
Protein Name Arfaptin-1
Adp-Ribosylation Factor-Interacting Protein 1
Database Links
Cellular Localisation Golgi Apparatus
Trans-Golgi Network Membrane
Alternative Protein Names Arfaptin-1 protein
Adp-Ribosylation Factor-Interacting Protein 1 protein
ARFIP1 protein

Information sourced from Uniprot.org

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