| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.073ng/mL |
| Detection Limit: | 0.156-10ng/mL |
| Short Description: | This APOO Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human serum, plasma, tissue homogenates or other biological fluids.. |
| Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 4.5 hrs |
| Gene Symbol: | APOO |
| Gene ID: | 79135 |
| Uniprot ID: | MIC26_HUMAN |
| Sample Type: | serum, plasma, tissue homogenates or other biological fluids. |
| Tissue Specificity | Expressed in all tissues examined. Up-regulated in diabetic heart. |
| Post Translational Modifications | O-glycosylation.glycosaminoglycan of chondroitin-sulfate type. |
| Function | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function. Can promote cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts. Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL. |
| Protein Name | Micos Complex Subunit Mic26 Apolipoprotein O Micos Complex Subunit Mic23 Protein Fam121b |
| Database Links | Reactome: R-HSA-8949613 |
| Cellular Localisation | Mitochondrion Inner Membrane Single-Pass Membrane Protein Secreted Mitochondrion Golgi Apparatus Membrane Endoplasmic Reticulum Membrane Exists In Three Distinct Forms: A Glycosylated And Secreted Form An Er/Golgi-Resident Form And A Non-Glycosylated Mitochondrial Form |
| Alternative ELISA Names | Micos Complex Subunit Mic26 ELISA kit Apolipoprotein O ELISA kit Micos Complex Subunit Mic23 ELISA kit Protein Fam121b ELISA kit APOO ELISA kit FAM121B ELISA kit MIC23 ELISA kit MIC26 ELISA kit My025 ELISA kit UNQ1866 ELISA kit PRO4302 ELISA kit |
| output |
Information sourced from Uniprot.org
