| Host: | E. coli |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Recombinant-Human Apolipoprotein A-I/APOA1-No tag protein was developed from e. coli and has a target region of No tag. For use in research applications. |
| Formulation: | Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation. |
| Gene Symbol: | APOA1 |
| Gene ID: | 335 |
| Uniprot ID: | APOA1_HUMAN |
| Immunogen: | Recombinant Human Apolipoprotein A-I/APOA1 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Asp25-Gln267) of human Apolipoprotein A-I (Accession #NP_000030.1). |
| Tissue Specificity | Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking. It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease. |
| Post Translational Modifications | Glycosylated. Palmitoylated. Phosphorylation sites are present in the extracellular medium. |
| Function | Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. |
| Protein Name | Apolipoprotein A-IApo-AiApoa-IApolipoprotein A1 Cleaved Into - Proapolipoprotein A-IProapoa-I - Truncated Apolipoprotein A-IApolipoprotein A-I(1-242 |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-1369062Reactome: R-HSA-1989781Reactome: R-HSA-2168880Reactome: R-HSA-3000471Reactome: R-HSA-3000480Reactome: R-HSA-381426Reactome: R-HSA-5682113Reactome: R-HSA-8957275Reactome: R-HSA-8963888Reactome: R-HSA-8963896Reactome: R-HSA-8963901Reactome: R-HSA-8964011Reactome: R-HSA-8964058Reactome: R-HSA-9707616Reactome: R-HSA-975634Reactome: R-HSA-977225 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Apolipoprotein A-I proteinApo-Ai proteinApoa-I proteinApolipoprotein A1 Cleaved Into - Proapolipoprotein A-I proteinProapoa-I - Truncated Apolipoprotein A-I proteinApolipoprotein A-I(1-242 proteinAPOA1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
