Tissue Specificity | Liver and plasma. |
Post Translational Modifications | Phosphorylated by FAM20C in the extracellular medium. |
Function | Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and an inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. Binds heparin. |
Protein Name | Apolipoprotein A-VApo-AvApoa-VApolipoprotein A5Regeneration-Associated Protein 3 |
Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-381426Reactome: R-HSA-8957275Reactome: R-HSA-8963889Reactome: R-HSA-8963901 |
Cellular Localisation | SecretedEarly EndosomeLate EndosomeGolgi ApparatusTrans-Golgi NetworkIn The Presence Of Sorl1Internalized To Early EndosomesSorted In A Retrograde Fashion To Late EndosomesFrom Which A Portion Is Sent To Lysosomes And DegradationAnother Portion Is Sorted To The Trans-Golgi Network |
Alternative ELISA Names | Apolipoprotein A-V ELISA kitApo-Av ELISA kitApoa-V ELISA kitApolipoprotein A5 ELISA kitRegeneration-Associated Protein 3 ELISA kitAPOA5 ELISA kitRAP3 ELISA kitUNQ411 ELISA kitPRO773 ELISA kit |
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Information sourced from Uniprot.org