Human APH1A protein (Recombinant) (N-GST & C-His) (STJP009046)

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STJP009046
£328.50 - £1,437.50
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human APH1A-N-GST & C-His protein was developed from e. coli and has a target region of N-GST & C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: APH1A
Gene ID: 51107
Uniprot ID: APH1A_HUMAN
Immunogen Region: Asn207-Asp265
Immunogen: Homo sapiens (Human)
Function Non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Required for normal gamma-secretase assembly. The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable).
Protein Name Gamma-Secretase Subunit Aph-1a
Aph-1a
Aph-1alpha
Presenilin-Stabilization Factor
Database Links Reactome: R-HSA-1251985
Reactome: R-HSA-193692
Reactome: R-HSA-205043
Reactome: R-HSA-2122948
Reactome: R-HSA-2644606
Reactome: R-HSA-2894862
Reactome: R-HSA-2979096
Reactome: R-HSA-3928665
Reactome: R-HSA-9013507
Reactome: R-HSA-9013700
Reactome: R-HSA-9017802
Reactome: R-HSA-977225
Reactome: R-HSA-9839383
Cellular Localisation Endoplasmic Reticulum Membrane
Multi-Pass Membrane Protein
Golgi Apparatus
Golgi Stack Membrane
Predominantly Located In The Endoplasmic Reticulum And In The Cis-Golgi
Alternative Protein Names Gamma-Secretase Subunit Aph-1a protein
Aph-1a protein
Aph-1alpha protein
Presenilin-Stabilization Factor protein
APH1A protein
PSF protein
CGI-78 protein
UNQ579 protein
PRO1141 protein

Information sourced from Uniprot.org