| Post Translational Modifications | Phosphorylation at Tyr-737 by SRC occurs at the plasma membrane in clathrin-coated vesicles (CCVs). |
| Function | Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-FILMV (Y-X-X-Phi) and ED-X-X-X-L-LI endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10. The AP-2 beta subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins.at least some clathrin-associated sorting proteins (CLASPs) are recognized by their DE-X(1,2)-F-X-X-FL-X-X-X-R motif. The AP-2 beta subunit binds to clathrin heavy chain, promoting clathrin lattice assembly.clathrin displaces at least some CLASPs from AP2B1 which probably then can be positioned for further coat assembly. |
| Protein Name | Ap-2 Complex Subunit BetaAp105bAdaptor Protein Complex Ap-2 Subunit BetaAdaptor-Related Protein Complex 2 Subunit BetaBeta-2-AdaptinBeta-AdaptinClathrin Assembly Protein Complex 2 Beta Large ChainPlasma Membrane Adaptor Ha2/Ap2 Adaptin Beta Subunit |
| Database Links | Reactome: R-HSA-167590Reactome: R-HSA-177504Reactome: R-HSA-182218Reactome: R-HSA-2132295Reactome: R-HSA-3928665Reactome: R-HSA-416993 P63010-1Reactome: R-HSA-437239Reactome: R-HSA-5099900Reactome: R-HSA-5140745Reactome: R-HSA-8856825Reactome: R-HSA-8856828Reactome: R-HSA-8866427Reactome: R-HSA-8964038Reactome: R-HSA-9679191 |
| Cellular Localisation | Cell MembraneMembraneCoated PitPeripheral Membrane ProteinCytoplasmic SideAp-2 Appears To Be Excluded From Internalizing Ccvs And To Disengage From Sites Of Endocytosis Seconds Before Internalization Of The Nascent Ccv |
| Alternative Protein Names | Ap-2 Complex Subunit Beta proteinAp105b proteinAdaptor Protein Complex Ap-2 Subunit Beta proteinAdaptor-Related Protein Complex 2 Subunit Beta proteinBeta-2-Adaptin proteinBeta-Adaptin proteinClathrin Assembly Protein Complex 2 Beta Large Chain proteinPlasma Membrane Adaptor Ha2/Ap2 Adaptin Beta Subunit proteinAP2B1 proteinADTB2 proteinCLAPB1 protein |
Information sourced from Uniprot.org
