Human ANTXR1/TEM8 protein (Recombinant-Active) (C-His) (STJP012266)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Active-Human ANTXR1/TEM8-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity | Measured by its binding ability in a functional ELISA. When Anthrax Protective Antigen is coated at 1.5 Mu g/mL (100 Mu L/well) , the concentration of recombinant human ANTXR1/TEM8 that produces 50% optimal binding response is 0.6-3.6 Mu g/mL. |
Target Information
| Gene Symbol | ANTXR1 |
| Gene ID | 84168 |
| Uniprot ID | ANTR1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Glu33-Ser321 |
Additional Info
| Post Translational Modifications | Glycosylated. Glycosylation is essential for Seneca Valley virus (SVV) attachment and entry. Phosphorylated upon PLAU binding. |
| Function | Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton and thereby plays an important role in normal extracellular matrix (ECM) homeostasis. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. May also act as a receptor for PLAU. Upon ligand binding, stimulates the phosphorylation of EGFR and ERK1/2. (Microbial infection) Acts as a receptor for protective antigen (PA) of B.anthracis. (Microbial infection) Mediates cell entry of Seneca Valley virus (SVV) when glycosylated. |
| Protein Name | Anthrax Toxin Receptor 1Tumor Endothelial Marker 8 |
| Database Links | Reactome: R-HSA-5210891 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell ProjectionLamellipodium MembraneFilopodium MembraneAt The Membrane Of Lamellipodia And At The Tip Of Actin-Enriched FilopodiaColocalizes With Actin At The Base Of Lamellipodia |
| Alternative Protein Names | Anthrax Toxin Receptor 1 proteinTumor Endothelial Marker 8 proteinANTXR1 proteinATR proteinTEM8 protein |
Information sourced from Uniprot.org