| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.127ng/mL |
| Detection Limit: | 0.312-20ng/mL |
| Short Description : | This ANO6 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates or other biological fluids.. |
| Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 4.5 hrs |
| Gene Symbol: | ANO6 |
| Gene ID: | 196527 |
| Uniprot ID: | ANO6_HUMAN |
| Sample Type: | tissue homogenates or other biological fluids. |
| Tissue Specificity | Expressed in embryonic stem cell, fetal liver, retina, chronic myologenous leukemia and intestinal cancer. |
| Post Translational Modifications | |
| Function | Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity.scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes. (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, is activated by spike protein which increases the amplitude of spontaneous Ca(2+) signals and is required for spike-mediated syncytia. |
| Protein Name | Anoctamin-6 Small-Conductance Calcium-Activated Nonselective Cation Channel Scan Channel Transmembrane Protein 16f |
| Database Links | Reactome: R-HSA-2672351 Reactome: R-HSA-6798695 Reactome: R-HSA-9733458 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Shows An Intracellular Localization |
| Alternative ELISA Names | Anoctamin-6 ELISA kit Small-Conductance Calcium-Activated Nonselective Cation Channel ELISA kit Scan Channel ELISA kit Transmembrane Protein 16f ELISA kit ANO6 ELISA kit TMEM16F ELISA kit |
| output |
Information sourced from Uniprot.org