Function | Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina. |
Protein Name | Anoctamin-2Transmembrane Protein 16b |
Database Links | Reactome: R-HSA-2672351Reactome: R-HSA-381753Reactome: R-HSA-9733458 |
Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
Alternative Protein Names | Anoctamin-2 proteinTransmembrane Protein 16b proteinANO2 proteinC12orf3 proteinTMEM16B protein |
Information sourced from Uniprot.org