• Human Angiopoietin-like 4/ANGPTL4 protein (Recombinant) (N-His) (STJP002072)

Human Angiopoietin-like 4/ANGPTL4 protein (Recombinant) (N-His) (STJP002072)

SKU:
STJP002072

£93.50 - £357.50
Current Stock:
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human Angiopoietin-like 4/ANGPTL4-N-His protein was developed from hek293 cells and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a 0.2 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ANGPTL4
Gene ID: 51129
Uniprot ID: ANGL4_HUMAN
Immunogen Region: Pro166-Ser406
Immunogen: Recombinant Human Angiopoietin-like 4/ANGPTL4 Protein is produced by Mammalian expression system. The target protein is expressed with sequence (Pro166-Ser406) of human ANGPTL4 (Accession #Q9BY76) fused with a 6xHis tag at the N-terminus.
Post Translational Modifications N-glycosylated. ANGPTL4 N-terminal chain: Forms disulfide-linked dimers and tetramers. Cleaved into a smaller N-terminal chain and a larger chain that contains the fibrinogen C-terminal domain.both cleaved and uncleaved forms are detected in the extracellular space. The cleaved form is not present within the cell.
Function Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. May also play a role in regulating glucose homeostasis and insulin sensitivity (Probable). Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stress fibers and focal adhesions in endothelial cells that have adhered to ANGPTL4-containing ECM (in vitro). Depending on context, may modulate tumor-related angiogenesis. ANGPTL4 N-terminal chain: Mediates inactivation of the lipoprotein lipase LPL, and thereby plays an important role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. Has higher activity in LPL inactivation than the uncleaved protein.
Protein Name Angiopoietin-Related Protein 4
Angiopoietin-Like Protein 4
Hepatic Fibrinogen/Angiopoietin-Related Protein
Hfarp Cleaved Into - Angptl4 N-Terminal Chain - Angptl4 C-Terminal Chain
Database Links Reactome: R-HSA-1989781
Reactome: R-HSA-381340
Reactome: R-HSA-8963889
Reactome: R-HSA-9762292
Cellular Localisation Secreted
Extracellular Space
Extracellular Matrix
The Unprocessed Form Interacts With The Extracellular Matrix
This May Constitute A Dynamic Reservoir
A Regulatory Mechanism Of The Bioavailability Of Angptl4 (Probable)
Alternative Protein Names Angiopoietin-Related Protein 4 protein
Angiopoietin-Like Protein 4 protein
Hepatic Fibrinogen/Angiopoietin-Related Protein protein
Hfarp Cleaved Into - Angptl4 N-Terminal Chain - Angptl4 C-Terminal Chain protein
ANGPTL4 protein
ARP4 protein
HFARP protein
PGAR protein
PP1158 protein
PSEC0166 protein
UNQ171 protein
PRO197 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance