Human AMSH/STAMBP protein (Recombinant) (His-Tag) (STJP018030)

Name: Human AMSH/STAMBP protein (Recombinant) (His-Tag) (STJP018030)
SKU: STJP018030
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostE.coli

ImmunogenHuman

STJP018030

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Short Description	Recombinant-Human AMSH/STAMBP-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications	SDS-PAGE
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Concentration	1 mg/mL
Formulation	Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% Glycerol, 1mM DTT
Storage Instruction	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.

Gene Symbol	STAMBP
Gene ID	10617
Uniprot ID	STABP_HUMAN
Accession Number	NP_998787.1
Immunogen	Human
Immunogen Region	1-424aa
Immunogen Sequence	MSDHGDV SLPPEDRVRA LSQLGSAVEV NEDIPPRRYF RSGVEIIRMA SIYSEEGNIE HAFILYNKYI TLFIEKLPKH RDYKSAVIPE KKDTVKKLKE IAFPKAEELK AELLKRYTKE YTEYNEEKKK EAEELARNMA IQQELEKEKQ RVAQQKQQQL EQEQFHAFEE MIRNQELEKE RLKIVQEFGK VDPGLGGPLV PDLEKP

Tissue Specificity	Ubiquitously expressed.
Post Translational Modifications	Phosphorylated after BMP type I receptor activation. Ubiquitinated by SMURF2 in the presence of RNF11.
Function	Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization. Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways.
Protein Name	Stam-Binding Protein Associated Molecule With The Sh3 Domain Of Stam Endosome-Associated Ubiquitin Isopeptidase
Database Links	Reactome: R-HSA-5689901
Cellular Localisation	Nucleus Membrane Peripheral Membrane Protein Cytoplasm Early Endosome
Alternative Protein Names	Stam-Binding Protein protein Associated Molecule With The Sh3 Domain Of Stam protein Endosome-Associated Ubiquitin Isopeptidase protein STAMBP protein AMSH protein

Information sourced from Uniprot.org