Human AMSH/STAMBP protein (Recombinant) (His-Tag) (STJP018030)

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STJP018030
£134.50 - £738.50
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human AMSH/STAMBP-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% Glycerol, 1mM DTT
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: STAMBP
Gene ID: 10617
Uniprot ID: STABP_HUMAN
Immunogen Region: 1-424aa
Accession Number: NP_998787.1
Immunogen: Human
Immunogen Sequence: MSDHGDV SLPPEDRVRA LSQLGSAVEV NEDIPPRRYF RSGVEIIRMA SIYSEEGNIE HAFILYNKYI TLFIEKLPKH RDYKSAVIPE KKDTVKKLKE IAFPKAEELK AELLKRYTKE YTEYNEEKKK EAEELARNMA IQQELEKEKQ RVAQQKQQQL EQEQFHAFEE MIRNQELEKE RLKIVQEFGK VDPGLGGPLV PDLEKP
Tissue Specificity Ubiquitously expressed.
Post Translational Modifications Phosphorylated after BMP type I receptor activation. Ubiquitinated by SMURF2 in the presence of RNF11.
Function Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization. Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways.
Protein Name Stam-Binding Protein
Associated Molecule With The Sh3 Domain Of Stam
Endosome-Associated Ubiquitin Isopeptidase
Database Links Reactome: R-HSA-5689901
Cellular Localisation Nucleus
Membrane
Peripheral Membrane Protein
Cytoplasm
Early Endosome
Alternative Protein Names Stam-Binding Protein protein
Associated Molecule With The Sh3 Domain Of Stam protein
Endosome-Associated Ubiquitin Isopeptidase protein
STAMBP protein
AMSH protein

Information sourced from Uniprot.org

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