Human AMH protein (Recombinant) (C-Fc) (STJP003635)

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STJP003635
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Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human AMH-C-Fc protein was developed from mammalian cells and has a target region of C-Fc. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: AMH
Gene ID: 268
Uniprot ID: MIS_HUMAN
Immunogen Region: Met1-Arg560
Immunogen: Homo sapiens (Human)
Post Translational Modifications Preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active non-covalent complex. Binding of the non-covalent complex to AMHR2 induces dissociation of the pro-region from the mature C-terminal dimer. The N-terminal portion of the protein, despite having no intrinsic activity, has the role of amplifying the activity of the C-terminus.
Function Plays an important role in several reproductive functions. Induces Muellerian duct regression during male fetal sexual differentiation. Also plays a role in Leydig cell differentiation and function. In female acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles. AMH signals by binding to a specific type-II receptor, AMHR2, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A), and recruiting SMAD proteins that are translocated to the nucleus to regulate target gene expression.
Protein Name Muellerian-Inhibiting Factor
Anti-Muellerian Hormone
Amh
Muellerian-Inhibiting Substance
Mis
Database Links Reactome: R-HSA-201451
Reactome: R-HSA-9690406
Cellular Localisation Secreted
Alternative Protein Names Muellerian-Inhibiting Factor protein
Anti-Muellerian Hormone protein
Amh protein
Muellerian-Inhibiting Substance protein
Mis protein
AMH protein
MIF protein

Information sourced from Uniprot.org

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