| Host: | E.coli |
| Applications: | SDS-PAGE |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human alpha-Actinin 1/ACTN1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Formulation: | Liquid in phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol |
| Concentration: | 1 mg/mL |
| Storage Instruction: | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ACTN1 |
| Gene ID: | 87 |
| Uniprot ID: | ACTN1_HUMAN |
| Immunogen Region: | 1-249aa |
| Accession Number: | NP_001123476 |
| Immunogen: | Human |
| Immunogen Sequence: | MGSSHHHHHH SSGLVPRGSH MGSEFMDHYD SQQTNDYMQP EEDWDRDLLL DPAWEKQQRK TFTAWCNSHL RKAGTQIENI EEDFRDGLKL MLLLEVISGE RLAKPERGKM RVHKISNVNK ALDFIASKGV KLVSIGAEEI VDGNVKMTLG MIWTIILRFA IQDISVEETS AKEGLLLWCQ RKTAPYKNVN IQNFHISWKD GLGFCALIHR HRPELIDYGK LRKDDPLT |
| Function | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation. |
| Protein Name | Alpha-Actinin-1Alpha-Actinin Cytoskeletal IsoformF-Actin Cross-Linking ProteinNon-Muscle Alpha-Actinin-1 |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-3000170Reactome: R-HSA-373753Reactome: R-HSA-446388Reactome: R-HSA-9013405Reactome: R-HSA-9013418Reactome: R-HSA-9035034 |
| Cellular Localisation | CytoplasmCytoskeletonMyofibrilSarcomereZ LineCell MembraneCell JunctionCell ProjectionRuffleColocalizes With Myoz2 And Ppp3ca At The Z-Line Of Heart And Skeletal MuscleColocalizes With Psd In Membrane Ruffles And Central Reticular Structures |
| Alternative Protein Names | Alpha-Actinin-1 proteinAlpha-Actinin Cytoskeletal Isoform proteinF-Actin Cross-Linking Protein proteinNon-Muscle Alpha-Actinin-1 proteinACTN1 protein |
Information sourced from Uniprot.org