Function | Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes. |
Protein Name | Delta-1-Pyrroline-5-Carboxylate Dehydrogenase - MitochondrialP5c DehydrogenaseAldehyde Dehydrogenase Family 4 Member A1L-Glutamate Gamma-Semialdehyde Dehydrogenase |
Database Links | Reactome: R-HSA-389661Reactome: R-HSA-70688 |
Cellular Localisation | Mitochondrion Matrix |
Alternative Protein Names | Delta-1-Pyrroline-5-Carboxylate Dehydrogenase - Mitochondrial proteinP5c Dehydrogenase proteinAldehyde Dehydrogenase Family 4 Member A1 proteinL-Glutamate Gamma-Semialdehyde Dehydrogenase proteinALDH4A1 proteinALDH4 proteinP5CDH protein |
Information sourced from Uniprot.org