Human ALAS2 protein (Recombinant) (N-His) (STJP004351)

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STJP004351
€410.63 - €1,796.88
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ALAS2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: ALAS2
Gene ID: 212
Uniprot ID: HEM0_HUMAN
Immunogen Region: Ala361-Ala587
Immunogen: Homo sapiens (Human)
Function Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products. Contributes significantly to heme formation during erythropoiesis. Isoform 3: Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products. Catalytic activity is 75-85% of isoform 1 activity. Isoform 4: Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products. Catalytic activity is 65-75% of isoform 1 activity.
Protein Name 5-Aminolevulinate Synthase - Erythroid-Specific - Mitochondrial
Alas-E
5-Aminolevulinic Acid Synthase 2
Delta-Ala Synthase 2
Delta-Aminolevulinate Synthase 2
Database Links Reactome: R-HSA-189451
Cellular Localisation Mitochondrion Inner Membrane
Peripheral Membrane Protein
Localizes To The Matrix Side Of The Mitochondrion Inner Membrane
Isoform 4: Mitochondrion Inner Membrane
Alternative Protein Names 5-Aminolevulinate Synthase - Erythroid-Specific - Mitochondrial protein
Alas-E protein
5-Aminolevulinic Acid Synthase 2 protein
Delta-Ala Synthase 2 protein
Delta-Aminolevulinate Synthase 2 protein
ALAS2 protein
ALASE protein
ASB protein

Information sourced from Uniprot.org