Human AKR1C4 protein (Recombinant) (N-GST) (STJP004194)

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STJP004194
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human AKR1C4-N-GST protein was developed from e. coli and has a target region of N-GST. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: AKR1C4
Gene ID: 1109
Uniprot ID: AK1C4_HUMAN
Immunogen Region: Met1-Tyr323
Immunogen: Homo sapiens (Human)
Post Translational Modifications The N-terminus is blocked.
Function Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Liver specific enzyme that acts as an NAD(P)(H)-dependent 3-, 17- and 20-ketosteroid reductase on the steroid nucleus and side chain. Displays the ability to catalyze both oxidation and reduction in vitro, but most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentration of NADPH. Acts preferentially as a 3-alpha-hydroxysteroid dehydrogenase (HSD) with a subsidiary 3-beta-HSD activity. Catalyzes efficiently the transformation of the potent androgen 5-alpha-dihydrotestosterone (5alpha-DHT or 17beta-hydroxy-5alpha-androstan-3-one) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Catalyzes the reduction of estrone into 17beta-estradiol but with low efficiency. Metabolizes a broad spectrum of natural and synthetic therapeutic steroid and plays an important role in metabolism of androgens, estrogens, progestereone and conjugated steroids. Catalyzes the biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leading to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.
Protein Name Aldo-Keto Reductase Family 1 Member C4
3-Alpha-Hydroxysteroid Dehydrogenase Type I
3-Alpha-Hsd1
3alpha-Hydroxysteroid 3-Dehydrogenase
Chlordecone Reductase
Cdr
Dihydrodiol Dehydrogenase 4
Dd-4
Dd4
Hakra
Database Links Reactome: R-HSA-193368
Reactome: R-HSA-193775
Reactome: R-HSA-193807
Reactome: R-HSA-975634
Cellular Localisation Cytoplasm
Cytosol
Alternative Protein Names Aldo-Keto Reductase Family 1 Member C4 protein
3-Alpha-Hydroxysteroid Dehydrogenase Type I protein
3-Alpha-Hsd1 protein
3alpha-Hydroxysteroid 3-Dehydrogenase protein
Chlordecone Reductase protein
Cdr protein
Dihydrodiol Dehydrogenase 4 protein
Dd-4 protein
Dd4 protein
Hakra protein
AKR1C4 protein
CHDR protein

Information sourced from Uniprot.org

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