| Function | Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentrations of NADPH. Displays a broad positional specificity acting on positions 3, 17 and 20 of steroids and regulates the metabolism of hormones like estrogens and androgens. Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha-DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). Also specifically able to produce 17beta-hydroxy-5alpha-androstan-3-one/5alphaDHT. May also reduce conjugated steroids such as 5alpha-dihydrotestosterone sulfate. Displays affinity for bile acids. |
| Protein Name | Aldo-Keto Reductase Family 1 Member C2 3-Alpha-Hsd3Chlordecone Reductase Homolog HakrdDihydrodiol Dehydrogenase 2Dd-2Dd2Dihydrodiol Dehydrogenase/Bile Acid-Binding ProteinDd/BabpType Iii 3-Alpha-Hydroxysteroid Dehydrogenase |
| Database Links | Reactome: R-HSA-193368Reactome: R-HSA-193775Reactome: R-HSA-193807 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Protein Names | Aldo-Keto Reductase Family 1 Member C2 protein3-Alpha-Hsd3 proteinChlordecone Reductase Homolog Hakrd proteinDihydrodiol Dehydrogenase 2 proteinDd-2 proteinDd2 proteinDihydrodiol Dehydrogenase/Bile Acid-Binding Protein proteinDd/Babp proteinType Iii 3-Alpha-Hydroxysteroid Dehydrogenase proteinAKR1C2 proteinDDH2 protein |
Information sourced from Uniprot.org
