| Function | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engages and activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation. UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex. |
| Protein Name | Proteasomal Ubiquitin Receptor Adrm1110 Kda Cell Membrane GlycoproteinGp110Adhesion-Regulating Molecule 1Arm-1Proteasome Regulatory Particle Non-Atpase 13Hrpn13Rpn13 Homolog |
| Database Links | Reactome: R-HSA-5689603Reactome: R-HSA-5689880 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Protein Names | Proteasomal Ubiquitin Receptor Adrm1 protein110 Kda Cell Membrane GlycoproteinGp110 proteinAdhesion-Regulating Molecule 1 proteinArm-1 proteinProteasome Regulatory Particle Non-Atpase 13 proteinHrpn13 proteinRpn13 Homolog proteinADRM1 proteinGP110 protein |
Information sourced from Uniprot.org
