| Post Translational Modifications | Autoproteolytically processed at the GPS region of the GAIN-B domain.this cleavage modulates receptor activity. O- and N-glycosylated. |
| Function | Adhesion G-protein coupled receptor (aGPCR) for glucocorticoid hormones such as cortisol, cortisone and 11-deoxycortisol. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. ADGRG3/GPR97 is coupled to G(o)/GNAO1 G proteins and mediates signaling by inhibiting adenylate cyclase activity. May also signal through G-alpha(q)-proteins.additional evidence are however required to confirm this result in vivo. Plays a role in the regulation of various processes including B-cell development, inflammation or innate immunity. Regulates migration of lymphatic endothelial cells in vitro via the small GTPases RhoA and CDC42. Antibody ligation leads to the production and activation of antimicrobial mediators like reactive oxygen species (ROS) and myeloperoxidase (MPO) as well as enhanced bacteria uptake and killing by granulocytes. Additionally, collaborates with protease-activated receptor 2/PAR2 to stimulate neutrophil-driven antimicrobial responses and endothelial cell activation. |
| Protein Name | Adhesion G Protein-Coupled Receptor G3G-Protein Coupled Receptor 97 Cleaved Into - Adhesion G-Protein Coupled Receptor G3 - N-Terminal FragmentAdgrg3 N-Terminal Fragment - Adhesion G-Protein Coupled Receptor G3 - C-Terminal FragmentAdgrg3 C-Terminal Fragment |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Protein Names | Adhesion G Protein-Coupled Receptor G3 proteinG-Protein Coupled Receptor 97 Cleaved Into - Adhesion G-Protein Coupled Receptor G3 - N-Terminal Fragment proteinAdgrg3 N-Terminal Fragment - Adhesion G-Protein Coupled Receptor G3 - C-Terminal Fragment proteinAdgrg3 C-Terminal Fragment proteinADGRG3 proteinGPR97 proteinPGR26 protein |
Information sourced from Uniprot.org
