Human ADGRB1 protein (Recombinant) (N-GST) (STJP003178)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ADGRB1-N-GST protein was developed from e.coli for the region N-GST. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | ADGRB1 |
| Gene ID | 575 |
| Uniprot ID | AGRB1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ala31-Pro350 |
Additional Info
| Post Translational Modifications | Proteolytically cleaved to produce vasculostatin-40 and vasculostatin-120. Vasculostatin-40 is the major form and is produced through proteolytic cleavage by MMP14 between residues 321 and 329 with cleavage likely to be between Ser-326 and Leu-327. Ubiquitinated. |
| Function | Phosphatidylserine receptor which enhances the engulfment of apoptotic cells. Also mediates the binding and engulfment of Gram-negative bacteria. Stimulates production of reactive oxygen species by macrophages in response to Gram-negative bacteria, resulting in enhanced microbicidal macrophage activity. In the gastric mucosa, required for recognition and engulfment of apoptotic gastric epithelial cells. Promotes myoblast fusion. Activates the Rho pathway in a G-protein-dependent manner. Inhibits MDM2-mediated ubiquitination and degradation of DLG4/PSD95, promoting DLG4 stability and regulating synaptic plasticity. Required for the formation of dendritic spines by ensuring the correct localization of PARD3 and TIAM1. Potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53/TP53 signal in suppression of glioblastoma. Vasculostatin-120: Inhibits angiogenesis in a CD36-dependent manner. Vasculostatin-40: Inhibits angiogenesis. |
| Protein Name | Adhesion G Protein-Coupled Receptor B1Brain-Specific Angiogenesis Inhibitor 1 Cleaved Into - Vasculostatin-40Vstat40 - Vasculostatin-120Vstat120 |
| Database Links | |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionPhagocytic CupCell JunctionFocal AdhesionDendritic SpinePostsynaptic DensityVasculostatin-120: SecretedVasculostatin-40: Secreted |
| Alternative Protein Names | Adhesion G Protein-Coupled Receptor B1 proteinBrain-Specific Angiogenesis Inhibitor 1 Cleaved Into - Vasculostatin-40 proteinVstat40 - Vasculostatin-120 proteinVstat120 proteinADGRB1 proteinBAI1 protein |
Information sourced from Uniprot.org