Human ADGRB1 protein (Recombinant) (N-GST) (STJP003178)

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STJP003178
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ADGRB1-N-GST protein was developed from e. coli and has a target region of N-GST. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: ADGRB1
Gene ID: 575
Uniprot ID: AGRB1_HUMAN
Immunogen Region: Ala31-Pro350
Immunogen: Homo sapiens (Human)
Post Translational Modifications Proteolytically cleaved to produce vasculostatin-40 and vasculostatin-120. Vasculostatin-40 is the major form and is produced through proteolytic cleavage by MMP14 between residues 321 and 329 with cleavage likely to be between Ser-326 and Leu-327. Ubiquitinated.
Function Phosphatidylserine receptor which enhances the engulfment of apoptotic cells. Also mediates the binding and engulfment of Gram-negative bacteria. Stimulates production of reactive oxygen species by macrophages in response to Gram-negative bacteria, resulting in enhanced microbicidal macrophage activity. In the gastric mucosa, required for recognition and engulfment of apoptotic gastric epithelial cells. Promotes myoblast fusion. Activates the Rho pathway in a G-protein-dependent manner. Inhibits MDM2-mediated ubiquitination and degradation of DLG4/PSD95, promoting DLG4 stability and regulating synaptic plasticity. Required for the formation of dendritic spines by ensuring the correct localization of PARD3 and TIAM1. Potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53/TP53 signal in suppression of glioblastoma. Vasculostatin-120: Inhibits angiogenesis in a CD36-dependent manner. Vasculostatin-40: Inhibits angiogenesis.
Protein Name Adhesion G Protein-Coupled Receptor B1
Brain-Specific Angiogenesis Inhibitor 1 Cleaved Into - Vasculostatin-40
Vstat40 - Vasculostatin-120
Vstat120
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Cell Projection
Phagocytic Cup
Cell Junction
Focal Adhesion
Dendritic Spine
Postsynaptic Density
Vasculostatin-120: Secreted
Vasculostatin-40: Secreted
Alternative Protein Names Adhesion G Protein-Coupled Receptor B1 protein
Brain-Specific Angiogenesis Inhibitor 1 Cleaved Into - Vasculostatin-40 protein
Vstat40 - Vasculostatin-120 protein
Vstat120 protein
ADGRB1 protein
BAI1 protein

Information sourced from Uniprot.org

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