| Post Translational Modifications | Phosphorylated by PKA.mediates inhibition of adenylate cyclase activity at membrane raft.does not influence either CALM1 or PPP2CA interaction with ADCY8. N-glycosylated.N-glycosylation is responsible for raft-targeting.is not necessary for CCE-stimulated adenylate cyclase activity. |
| Function | Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secretion. Plays a role in many brain functions, such as learning, memory, drug addiction, and anxiety modulation through regulation of synaptic plasticity by modulating long-term memory and long-term potentiation (LTP) through CREB transcription factor activity modulation. Plays a central role in insulin secretion by controlling glucose homeostasis through glucagon-like peptide 1 and glucose signaling pathway and maintains insulin secretion through calcium-dependent PKA activation leading to vesicle pool replenishment. Also, allows PTGER3 to induce potentiation of PTGER4-mediated PLA2 secretion by switching from a negative to a positive regulation, during the IL1B induced-dedifferentiation of smooth muscle cells. |
| Protein Name | Adenylate Cyclase Type 8Atp Pyrophosphate-Lyase 8Adenylate Cyclase Type ViiiAdenylyl Cyclase 8Ac8Ca(2+/Calmodulin-Activated Adenylyl Cyclase |
| Database Links | Reactome: R-HSA-163359Reactome: R-HSA-163615Reactome: R-HSA-164378Reactome: R-HSA-170660Reactome: R-HSA-170670Reactome: R-HSA-381676Reactome: R-HSA-418555Reactome: R-HSA-418594Reactome: R-HSA-418597Reactome: R-HSA-432040Reactome: R-HSA-442720Reactome: R-HSA-5610787Reactome: R-HSA-9634597Reactome: R-HSA-9660821Reactome: R-HSA-9664323 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneApical Cell MembraneSynapseCell ProjectionDendriteAxonPresynaptic Cell MembranePostsynaptic DensityMembrane RaftMembraneCoated PitCytoplasmic VesicleClathrin-Coated Vesicle MembraneCaveolaLocalized To Dendritic ArborsMonomeric N-Glycosylated Species Localizes In Membrane RaftIn ContrastMonomeric Unglycosylated Forms Are Enriched In Clathrin-Coated Pits And VesiclesDimers Are Also Localized Outside Of Membrane RaftsMembrane Raft Localization And Integrity Is Indispensable For Cce-Stimulated Adenylate Cyclase Activity |
| Alternative Protein Names | Adenylate Cyclase Type 8 proteinAtp Pyrophosphate-Lyase 8 proteinAdenylate Cyclase Type Viii proteinAdenylyl Cyclase 8 proteinAc8 proteinCa(2+/Calmodulin-Activated Adenylyl Cyclase proteinADCY8 protein |
Information sourced from Uniprot.org
