| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.049ng/mL |
| Detection Limit: | 0.156-10ng/mL |
| Short Description : | This ADAMTS6 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human serum, plasma, tissue homogenates or other biological fluids.. |
| Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 4.5 hrs |
| Gene Symbol: | ADAMTS6 |
| Gene ID: | 11174 |
| Uniprot ID: | ATS6_HUMAN |
| Sample Type: | serum, plasma, tissue homogenates or other biological fluids. |
| Tissue Specificity | Expressed at low levels in placenta and barely detectable in a number of other tissues. |
| Post Translational Modifications | The precursor is cleaved by a furin endopeptidase. Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion. |
| Function | |
| Protein Name | A Disintegrin And Metalloproteinase With Thrombospondin Motifs 6 Adam-Ts 6 Adam-Ts6 Adamts-6 |
| Database Links | Reactome: R-HSA-5083635 Reactome: R-HSA-5173214 |
| Cellular Localisation | Secreted Extracellular Space Extracellular Matrix |
| Alternative ELISA Names | A Disintegrin And Metalloproteinase With Thrombospondin Motifs 6 ELISA kit Adam-Ts 6 ELISA kit Adam-Ts6 ELISA kit Adamts-6 ELISA kit ADAMTS6 ELISA kit |
| output |
Information sourced from Uniprot.org