Tissue Specificity | Isoform 1 is expressed in placenta and skeletal, cardiac, and smooth muscle. Isoform 2 seems to be expressed only in placenta or in embryo and fetus. Both forms were expressed in some tumor cells lines. Not detected in brain, lung, liver, kidney or pancreas. |
Post Translational Modifications | The precursor is cleaved by a furin endopeptidase. |
Function | Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors. |
Protein Name | Disintegrin And Metalloproteinase Domain-Containing Protein 12Adam 12Meltrin-Alpha |
Database Links | Reactome: R-HSA-177929Reactome: R-HSA-8941237 |
Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: SecretedIsoform 3: SecretedIsoform 4: Secreted |
Alternative ELISA Names | Disintegrin And Metalloproteinase Domain-Containing Protein 12 ELISA kitAdam 12 ELISA kitMeltrin-Alpha ELISA kitADAM12 ELISA kitMLTN ELISA kitUNQ346 ELISA kitPRO545 ELISA kit |
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Information sourced from Uniprot.org