Human ADA/Adenosine deaminase protein (Recombinant) (N-His-SUMO) (STJP009588)

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STJP009588
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ADA/Adenosine deaminase-N-His-SUMO protein was developed from e. coli and has a target region of N-His-SUMO. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: ADA
Gene ID: 100
Uniprot ID: ADA_HUMAN
Immunogen Region: Thr57-Leu363
Immunogen: Homo sapiens (Human)
Function Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion. Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion. Enhances CD4+ T-cell differentiation and proliferation. Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change. Stimulates plasminogen activation. Plays a role in male fertility. Plays a protective role in early postimplantation embryonic development. Also responsible for the deamination of cordycepin (3'-deoxyadenosine), a fungal natural product that shows antitumor, antibacterial, antifungal, antivirus, and immune regulation properties.
Protein Name Adenosine Deaminase
Adenosine Aminohydrolase
Database Links Reactome: R-HSA-74217
Reactome: R-HSA-9734735
Reactome: R-HSA-9755088
Cellular Localisation Cell Membrane
Peripheral Membrane Protein
Extracellular Side
Cell Junction
Cytoplasmic Vesicle Lumen
Cytoplasm
Lysosome
Colocalized With Dpp4 At The Cell Surface
Alternative Protein Names Adenosine Deaminase protein
Adenosine Aminohydrolase protein
ADA protein
ADA1 protein

Information sourced from Uniprot.org