| Post Translational Modifications | Phosphorylated on tyrosine residues after serum stimulation or induction by v-Abl. Seems to be phosphorylated at Tyr-53 by ABL1, required for nuclear but not for synaptic localization. |
| Function | May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. |
| Protein Name | Abl Interactor 1Abelson Interactor 1Abi-1Abl-Binding Protein 4Ablbp4Eps8 Sh3 Domain-Binding ProteinEps8-Binding ProteinNap1-Binding ProteinNap1bpSpectrin Sh3 Domain-Binding Protein 1E3b1 |
| Database Links | Reactome: R-HSA-2029482Reactome: R-HSA-4420097Reactome: R-HSA-5663213Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013423Reactome: R-HSA-9664422 |
| Cellular Localisation | CytoplasmNucleusCell ProjectionLamellipodiumFilopodiumGrowth ConePostsynaptic DensityCytoskeletonLocalized To Protruding Lamellipodia And Filopodia TipsAlso Localized To Neuronal Growth Cones And SynaptosomesMay Shuttle From The Postsynaptic Densities To The Nucleus |
| Alternative Protein Names | Abl Interactor 1 proteinAbelson Interactor 1 proteinAbi-1 proteinAbl-Binding Protein 4 proteinAblbp4 proteinEps8 Sh3 Domain-Binding Protein proteinEps8-Binding Protein proteinNap1-Binding Protein proteinNap1bp proteinSpectrin Sh3 Domain-Binding Protein 1 proteinE3b1 proteinABI1 proteinSSH3BP1 protein |
Information sourced from Uniprot.org
