Human ABCG1 protein (Recombinant) (N-His) (STJP004758)

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STJP004758
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ABCG1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: ABCG1
Gene ID: 9619
Uniprot ID: ABCG1_HUMAN
Immunogen Region: Met1-His353
Immunogen: Homo sapiens (Human)
Post Translational Modifications Palmitoylation at Cys-315 seems important for trafficking from the endoplasmic reticulum.
Function Catalyzes the efflux of phospholipids such as sphingomyelin, cholesterol and its oxygenated derivatives like 7beta-hydroxycholesterol and this transport is coupled to hydrolysis of ATP. The lipid efflux is ALB-dependent. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol.
Protein Name Atp-Binding Cassette Sub-Family G Member 1
Atp-Binding Cassette Transporter 8
White Protein Homolog
Database Links Reactome: R-HSA-1369062
Reactome: R-HSA-8964058
Reactome: R-HSA-9029569
Cellular Localisation Endoplasmic Reticulum Membrane
Multi-Pass Membrane Protein
Golgi Apparatus Membrane
Cell Membrane
Predominantly Localized In The Intracellular Compartments Mainly Associated With The Endoplasmic Reticulum (Er) And Golgi Membranes
Alternative Protein Names Atp-Binding Cassette Sub-Family G Member 1 protein
Atp-Binding Cassette Transporter 8 protein
White Protein Homolog protein
ABCG1 protein
ABC8 protein
WHT1 protein

Information sourced from Uniprot.org

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