Human ABCE1 protein (Recombinant) (N-His) (STJP005016)

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STJP005016
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ABCE1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: ABCE1
Gene ID: 6059
Uniprot ID: ABCE1_HUMAN
Immunogen Region: Ile389-Asn556
Immunogen: Homo sapiens (Human)
Function Nucleoside-triphosphatase (NTPase) involved in ribosome recycling by mediating ribosome disassembly. Able to hydrolyze ATP, GTP, UTP and CTP. Splits ribosomes into free 60S subunits and tRNA- and mRNA-bound 40S subunits. Acts either after canonical termination facilitated by release factors (ETF1/eRF1) or after recognition of stalled and vacant ribosomes by mRNA surveillance factors (PELO/Pelota). Involved in the No-Go Decay (NGD) pathway: recruited to stalled ribosomes by the Pelota-HBS1L complex, and drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway. Also plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA. As part of the PINK1-regulated signaling, ubiquitinated by CNOT4 upon mitochondria damage.this modification generates polyubiquitin signals that recruit autophagy receptors to the mitochondrial outer membrane and initiate mitophagy. RNASEL-specific protein inhibitor which antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) to RNASEL. Negative regulator of the anti-viral effect of the interferon-regulated 2-5A/RNASEL pathway. (Microbial infection) May act as a chaperone for post-translational events during HIV-1 capsid assembly. (Microbial infection) Plays a role in the down-regulation of the 2-5A/RNASEL pathway during encephalomyocarditis virus (EMCV) and HIV-1 infections.
Protein Name Atp-Binding Cassette Sub-Family E Member 1
2'-5'-Oligoadenylate-Binding Protein
Huhp68
Rnase L Inhibitor
Ribonuclease 4 Inhibitor
Rns4i
Database Links Reactome: R-HSA-8983711
Reactome: R-HSA-909733
Cellular Localisation Cytoplasm
Mitochondrion
Alternative Protein Names Atp-Binding Cassette Sub-Family E Member 1 protein
2'-5'-Oligoadenylate-Binding Protein protein
Huhp68 protein
Rnase L Inhibitor protein
Ribonuclease 4 Inhibitor protein
Rns4i protein
ABCE1 protein
RLI protein
RNASEL1 protein
RNASELI protein
RNS4I protein
OK protein
SW-cl.40 protein

Information sourced from Uniprot.org

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