| Function | ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of endogenous metabolites such as cAMP and cGMP, folic acid and N-lactoyl-amino acids (in vitro). Acts also as a general glutamate conjugate and analog transporter that can limit the brain levels of endogenous metabolites, drugs, and toxins. Confers resistance to the antiviral agent PMEA. Able to transport several anticancer drugs including methotrexate, and nucleotide analogs in vitro, however it does with low affinity, thus the exact role of ABCC5 in mediating resistance still needs to be elucidated. Acts as a heme transporter required for the translocation of cytosolic heme to the secretory pathway. May play a role in energy metabolism by regulating the glucagon-like peptide 1 (GLP-1) secretion from enteroendocrine cells. |
| Protein Name | Atp-Binding Cassette Sub-Family C Member 5Multi-Specific Organic Anion Transporter CMoat-CMultidrug Resistance-Associated Protein 5SmrpPabc11 |
| Database Links | Reactome: R-HSA-2142850Reactome: R-HSA-382556Reactome: R-HSA-9748787Reactome: R-HSA-9753281 |
| Cellular Localisation | Basolateral Cell MembraneMulti-Pass Membrane ProteinGolgi Apparatus LumenEndosome MembraneCytoplasmic GranuleApical Cell MembraneIn Most CellsRoutes To The Basolateral Plasma MembraneBut In The Brain Capillary Endothelial Cells That Form The Blood-Brain BarrierResides In The Apical Membrane |
| Alternative Protein Names | Atp-Binding Cassette Sub-Family C Member 5 proteinMulti-Specific Organic Anion Transporter C proteinMoat-C proteinMultidrug Resistance-Associated Protein 5 proteinSmrp proteinPabc11 proteinABCC5 proteinMRP5 protein |
Information sourced from Uniprot.org
