| Tissue Specificity | Secreted in plasma. |
| Post Translational Modifications | |
| Function | Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. |
| Protein Name | Alpha-2-MacroglobulinAlpha-2-MC3 And Pzp-Like Alpha-2-Macroglobulin Domain-Containing Protein 5 |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-140837Reactome: R-HSA-1474228Reactome: R-HSA-8963896 |
| Cellular Localisation | Secreted |
| Alternative ELISA Names | Alpha-2-Macroglobulin ELISA kitAlpha-2-M ELISA kitC3 And Pzp-Like Alpha-2-Macroglobulin Domain-Containing Protein 5 ELISA kitA2M ELISA kitCPAMD5 ELISA kitFWP007 ELISA kit |
| output | |
Information sourced from Uniprot.org
