| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | It is uncertain whether palmitoylation is on Cys-561 and/or Cys-562 and/or Cys-565. |
| Function | Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). |
| Peptide Name | G Protein-Coupled Receptor Kinase 6G Protein-Coupled Receptor Kinase Grk6 |
| Database Links | Reactome: R-HSA-418555 |
| Cellular Localisation | MembraneLipid-Anchor |
| Alternative Peptide Names | G Protein-Coupled Receptor Kinase 6 proteinG Protein-Coupled Receptor Kinase Grk6 proteinGRK6 proteinGPRK6 protein |
Information sourced from Uniprot.org
