| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
GPR56 Blocking Peptide is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
ADGRG1 |
| Gene ID: |
9289 |
| Uniprot ID: |
AGRG1_HUMAN |
| Immunogen: |
Synthetic peptide taken from large extracellular loop of the human GPCR56 protein. Peptide was conjugated to Keyhole Limpet Haemocyanin (KLH). |
| Tissue Specificity | Widely distributed with highest levels found in thyroid gland, brain and heart. Expressed in a great number of tumor cells. Expression is down-regulated in different tumors from highly metastatic cells. |
| Post Translational Modifications | Autoproteolytically cleaved into 2 fragments.the large extracellular N-terminal fragment (ADGRG1 NT) and the membrane-bound C-terminal fragment (ADGRG1 CT) predominantly remain associated and non-covalently linked. Shedding to yield the secreted ADGRG1 N-terminal fragment seems to involve metalloprotease(s). N-glycosylated. Contains sialic acid residues. Ubiquitinated. Undergoes polyubiquitination upon activation. |
| Function | Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Plays a role in the maintenance of hematopoietic stem cells and/or leukemia stem cells in bone marrow niche. Plays a critical role in cancer progression by inhibiting VEGFA production threreby inhibiting angiogenesis through a signaling pathway mediated by PRKCA. Plays an essential role in testis development. ADGRG1 N-terminal fragment: Plays a critical role in cancer progression by activating VEGFA production and angiogenesis through a signaling pathway mediated by PRKCA. |
| Peptide Name | Adhesion G-Protein Coupled Receptor G1G-Protein Coupled Receptor 56Protein Tm7xn1 Cleaved Into - Adgrg1 N-Terminal FragmentAdgrg1 NtGpr56 N-Terminal FragmentGpr56 NtGpr56(NGpr56 Extracellular SubunitGpr56 Subunit Alpha - Adgrg1 C-Terminal FragmentAdgrg1 CtGpr56 C-Terminal FragmentGpr56 CtGpr56(CGpr56 Seven-Transmembrane SubunitGpr56 7tmGpr56 Subunit Beta |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinAdgrg1 N-Terminal Fragment: SecretedAdgrg1 C-Terminal Fragment: Membrane RaftInteraction With Its Ligand Col3a1 Leads To The Release Of Adgrg1 Nt From The Membrane And Triggers The Association Of Adgrg1 Ct With Lipid Rafts |
| Alternative Peptide Names | Adhesion G-Protein Coupled Receptor G1 proteinG-Protein Coupled Receptor 56 proteinProtein Tm7xn1 Cleaved Into - Adgrg1 N-Terminal Fragment proteinAdgrg1 Nt proteinGpr56 N-Terminal Fragment proteinGpr56 Nt proteinGpr56(N proteinGpr56 Extracellular Subunit proteinGpr56 Subunit Alpha - Adgrg1 C-Terminal Fragment proteinAdgrg1 Ct proteinGpr56 C-Terminal Fragment proteinGpr56 Ct proteinGpr56(C proteinGpr56 Seven-Transmembrane Subunit proteinGpr56 7tm proteinGpr56 Subunit Beta proteinADGRG1 proteinGPR56 proteinTM7LN4 proteinTM7XN1 proteinUNQ540 proteinPRO1083 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
