GPCR LGR6 Positive Control peptide (STJ504346)

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STJ504346-5
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Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : GPCR LGR6 Positive Control is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range: WB: 1:500
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: LGR6
Gene ID: 59352
Uniprot ID: LGR6_HUMAN
Function Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor.
Peptide Name Leucine-Rich Repeat-Containing G-Protein Coupled Receptor 6
Database Links Reactome: R-HSA-4641263
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Peptide Names Leucine-Rich Repeat-Containing G-Protein Coupled Receptor 6 protein
LGR6 protein
UNQ6427 protein
PRO21331 protein
VTS20631 protein

Information sourced from Uniprot.org

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