| Tissue Specificity | Abundantly expressed in granule neurons at all development stages. Enriched in the longest tips of neurites during differentiation of hippocampal neurons. |
| Function | Constitutively active G-protein coupled receptor that maintains high 3'-5'-cyclic adenosine monophosphate (cAMP) levels that a plays a role in serveral processes including meiotic arrest in oocytes or neuronal development via activation of numerous intracellular signaling pathways. Acts as an essential activator of thermogenic adipocytes and drives thermogenesis via its intrinsic G(s)-coupling activity without the requirement of a ligand. Has a potential role in modulating a number of brain functions, including behavioral responses to stress, amyloid-beta peptide generation in neurons. Stimulates neurite outgrowth in cerebellar granular neurons modulated via PKA, ERK, and most strongly PI3K-mediated signaling pathways. |
| Peptide Name | G-Protein Coupled Receptor 3G-Protein-Coupled Receptor R4 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Peptide Names | G-Protein Coupled Receptor 3 proteinG-Protein-Coupled Receptor R4 proteinGpr3 protein |
Information sourced from Uniprot.org
