Post Translational Modifications | Ubiquitinated by E3 ubiquitin ligase complex formed by CUL3 and RBX1 and probably targeted for proteasome-independent degradation. |
Function | Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of TBCB. Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival. |
Peptide Name | GigaxoninKelch-Like Protein 16 |
Database Links | Reactome: R-HSA-8951664Reactome: R-HSA-983168 |
Cellular Localisation | CytoplasmCytoskeleton |
Alternative Peptide Names | Gigaxonin proteinKelch-Like Protein 16 proteinGAN proteinGAN1 proteinKLHL16 protein |
Information sourced from Uniprot.org