GAN Positive Control for STJ507836 peptide (STJ507838)

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STJ507838-5
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Covered by St John's Laboratory Guarantee

Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : GAN Positive Control for STJ507836 is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: GAN
Gene ID: 8139
Uniprot ID: GAN_HUMAN
Specificity: This is positive control is recommended for use in combination with GAN antibody STJ507836.
Post Translational Modifications Ubiquitinated by E3 ubiquitin ligase complex formed by CUL3 and RBX1 and probably targeted for proteasome-independent degradation.
Function Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of TBCB. Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival.
Peptide Name Gigaxonin
Kelch-Like Protein 16
Database Links Reactome: R-HSA-8951664
Reactome: R-HSA-983168
Cellular Localisation Cytoplasm
Cytoskeleton
Alternative Peptide Names Gigaxonin protein
Kelch-Like Protein 16 protein
GAN protein
GAN1 protein
KLHL16 protein

Information sourced from Uniprot.org

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