Tissue Specificity | In adult, it is highly expressed in skeletal muscle, heart and brain. |
Post Translational Modifications | The extracellular domain is cleaved and released from the cell membrane. N-Glycosylated. |
Function | Irisin: Mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA. |
Peptide Name | Fibronectin Type Iii Domain-Containing Protein 5Fibronectin Type Iii Repeat-Containing Protein 2Peroxisomal ProteinPep Cleaved Into - Irisin |
Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinPeroxisome MembraneSecretedImported In Peroxisomes Through The Pex5 Receptor PathwayIrisin: SecretedDetected In The Blood Of Individuals Subjected To Endurance Exercise |
Alternative Peptide Names | Fibronectin Type Iii Domain-Containing Protein 5 proteinFibronectin Type Iii Repeat-Containing Protein 2 proteinPeroxisomal Protein proteinPep Cleaved Into - Irisin proteinFndc5 proteinFrcp2 proteinPep protein |
Information sourced from Uniprot.org