| Applications: | WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | EAAT2 Antibody Positve Control Positive Control is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: | WB: 1:500 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | SLC1A2 |
| Gene ID: | 6506 |
| Uniprot ID: | EAA2_HUMAN |
| Post Translational Modifications | Glycosylated. Palmitoylation at Cys-38 is not required for correct subcellular localization, but is important for glutamate uptake activity. |
| Function | Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport.this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate. |
| Peptide Name | Excitatory Amino Acid Transporter 2 Glutamate/Aspartate Transporter Ii Sodium-Dependent Glutamate/Aspartate Transporter 2 Solute Carrier Family 1 Member 2 |
| Database Links | Reactome: R-HSA-210455 Reactome: R-HSA-210500 Reactome: R-HSA-425393 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein |
| Alternative Peptide Names | Excitatory Amino Acid Transporter 2 protein Glutamate/Aspartate Transporter Ii protein Sodium-Dependent Glutamate/Aspartate Transporter 2 protein Solute Carrier Family 1 Member 2 protein SLC1A2 protein EAAT2 protein GLT1 protein |
Information sourced from Uniprot.org