| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
E2F4 Blocking Peptide for STJ500826 is synthetically produced from the 360-410 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
E2f4 |
| Gene ID: |
104394 |
| Uniprot ID: |
E2F4_MOUSE |
| Immunogen Region: |
360-410 |
| Specificity: |
This blocking peptide is recommended for use in combination with E2F4 antibody, STJ500826 |
| Immunogen: |
Synthetic peptide taken within amino acid region 360-410 on mouse E2F4 protein. |
| Post Translational Modifications | Differentially phosphorylated in vivo. |
| Function | Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTCCGCGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. |
| Peptide Name | Transcription Factor E2f4E2f-4 |
| Database Links | Reactome: R-MMU-1538133Reactome: -MMU-2173796Reactome: -MMU-69231 |
| Cellular Localisation | Nucleus |
| Alternative Peptide Names | Transcription Factor E2f4 proteinE2f-4 proteinE2f4 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
