| Applications: | Immunodepletion/Immunocompetition |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | E2F3 Blocking Peptide for STJ500822 is synthetically produced from the 70-120 sequence and is suitable for use in western blot applications. |
| Formulation: | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | E2f3 |
| Gene ID: | 13557 |
| Uniprot ID: | E2F3_MOUSE |
| Immunogen Region: | 70-120 |
| Specificity: | This blocking peptide is recommended for use in combination with E2F3 antibody, STJ500822 |
| Immunogen: | Synthetic peptide taken within amino acid region 70-120 on E2F3 protein. |
| Function | Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTCCGCGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters. |
| Peptide Name | Transcription Factor E2f3E2f-3 |
| Database Links | Reactome: R-MMU-68911Reactome: -MMU-69231 |
| Cellular Localisation | Nucleus |
| Alternative Peptide Names | Transcription Factor E2f3 proteinE2f-3 proteinE2f3 protein |
Information sourced from Uniprot.org