DYRK1 Blocking Peptide peptide (STJ505502)

SKU:
STJ505502-250

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Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: DYRK1 Blocking Peptide is synthetically produced from the 300-350 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: DYRK1A
Gene ID: 1859
Uniprot ID: DYR1A_HUMAN
Immunogen Region: 300-350
Immunogen: Synthetic peptide taken within amino acid region 300-350 on human Dual specificity tyrosine-phosphorylation-regulated kinase 1A.
Tissue Specificity Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.
Post Translational Modifications Autophosphorylated on numerous tyrosine residues. Can also autophosphorylate on serine and threonine residues (in vitro).
Function Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Plays an important role in double-strand breaks (DSBs) repair following DNA damage. Mechanistically, phosphorylates RNF169 and increases its ability to block accumulation of TP53BP1 at the DSB sites thereby promoting homologous recombination repair (HRR). Also acts as a positive regulator of transcription by acting as a CTD kinase that mediates phosphorylation of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits p53/TP53 activity and apoptosis. Phosphorylates SEPTIN4, SEPTIN5 and SF3B1 at 'Thr-434'.
Peptide Name Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1a
Dual Specificity Yak1-Related Kinase
Hp86
Protein Kinase Minibrain Homolog
Mnbh
Hmnb
Database Links Reactome: R-HSA-1538133
Cellular Localisation Nucleus
Nucleus Speckle
Alternative Peptide Names Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1a protein
Dual Specificity Yak1-Related Kinase protein
Hp86 protein
Protein Kinase Minibrain Homolog protein
Mnbh protein
Hmnb protein
DYRK1A protein
DYRK protein
MNB protein
MNBH protein

Information sourced from Uniprot.org

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