| Applications: |
WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
DWORF Positive Control for STJ500801 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: |
WB: 1:500 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Strit1Uniprot ID=DWORF_MOUSE" |
| Specificity: |
This is positive control is recommended for use in combination with DWORF antibody STJ500801. |
| Tissue Specificity | Highly expressed in heart (at protein level). Detected in heart and soleus, a postural muscle group of the hindlimb containing the highest enrichment of slow-twitch muscle fibers. Also expressed in diaphragm, which contains some slow-twitch fibers. Not detected in the quadriceps, a fast-twitch muscle group, or in cardiac atrial muscle. Not expressed in the prenatal heart but gradually increases in abundance postnatally. |
| Function | Enhances the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by displacing ATP2A1/SERCA1 inhibitors, thereby acting as a key regulator of skeletal muscle activity. Does not directly stimulate SERCA pump activity. Enhances sarcoplasmic reticulum Ca(2+) uptake and myocyte contractility by displacing the SERCA inhibitory peptides sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN). |
| Peptide Name | Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase Regulator DworfSerca Regulator DworfDwarf Open Reading FrameDworfSmall Transmembrane Regulator Of Ion Transport 1 |
| Cellular Localisation | Sarcoplasmic Reticulum MembraneSingle-Pass Membrane Protein |
| Alternative Peptide Names | Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase Regulator Dworf proteinSerca Regulator Dworf proteinDwarf Open Reading Frame proteinDworf proteinSmall Transmembrane Regulator Of Ion Transport 1 proteinStrit1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
