| Function | Required for transcriptional activation subsequent to the assembly of the pre-initiation complex. Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling. |
| Peptide Name | Mediator Of Rna Polymerase Ii Transcription Subunit 23Activator-Recruited Cofactor 130 Kda ComponentArc130Cofactor Required For Sp1 Transcriptional Activation Subunit 3Crsp Complex Subunit 3Mediator Complex Subunit 23Protein Sur-2 HomologHsur-2Transcriptional Coactivator Crsp130Vitamin D3 Receptor-Interacting Protein Complex 130 Kda ComponentDrip130 |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-212436Reactome: R-HSA-381340Reactome: R-HSA-9833110 |
| Cellular Localisation | Nucleus |
| Alternative Peptide Names | Mediator Of Rna Polymerase Ii Transcription Subunit 23 proteinActivator-Recruited Cofactor 130 Kda Component proteinArc130 proteinCofactor Required For Sp1 Transcriptional Activation Subunit 3 proteinCrsp Complex Subunit 3 proteinMediator Complex Subunit 23 proteinProtein Sur-2 Homolog proteinHsur-2 proteinTranscriptional Coactivator Crsp130 proteinVitamin D3 Receptor-Interacting Protein Complex 130 Kda Component proteinDrip130 proteinMED23 proteinARC130 proteinCRSP3 proteinDRIP130 proteinKIAA1216 proteinSUR2 protein |
Information sourced from Uniprot.org
