DNase I protein (STJP000146)

SKU:
STJP000146-50

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Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: DNase I-protein was developed from. For use in research applications.
Formulation: PBS pH 7.4
Purification: Purified by ion-exchange chromatography and gel-filtration from serum-free CHO growth media
Concentration: 0.5 mg/ml
Storage Instruction: Store at-70°C upon receipt. Recommended to aliquot into smaller quantities. Avoid repeated freeze-thaw cycles
Gene Symbol: DNASE1
Gene ID: 1773
Uniprot ID: DNAS1_HUMAN
Tissue Specificity Principally in tissues of the digestive system. Highest levels found in urine, but also relatively abundant in semen and saliva.
Function Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs. Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA. Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization. Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation. Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation.
Protein Name Deoxyribonuclease-1
Deoxyribonuclease I
Dnase I
Dornase Alfa
Cellular Localisation Secreted
Zymogen Granule
Nucleus Envelope
Secretory Protein
Stored In Zymogen Granules And Found In The Nuclear Envelope
Alternative Protein Names Deoxyribonuclease-1 protein
Deoxyribonuclease I protein
Dnase I protein
Dornase Alfa protein
DNASE1 protein
DNL1 protein
DRNI protein

Information sourced from Uniprot.org

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