| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 1 EU/Mu g of the protein by LAL method. |
| Immunogen Region: | Gln25-His559 |
| Immunogen: | Recombinant Cynomolgus Glypican-3/GPC3 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln25-His559) of cynomolgus Glypican-3/GPC3 (Accession #XP_005594665.1) fused with His tag at the C-terminus. |
| Immunogen Sequence: | QPPPPPPDATCHQVRSFFQR LQPGLKWVPETPVPGSDLQV CLPKGPTCCSRKMEEKYQLT ARLNMEQLLQSASMELKFLI IQNAAVFQEAFEIVVRHAKN YTNAMFKNNYPSLTPQAFEF VGEFFTDVSLYILGSDINVD DMVNELFDSLFPVIYTQLMN PGLPDSALDINECLRGARRD LKVFGNFPKLIMTQVSKSLQ VTRIFLQALNLGIEVINTTD HLKFSKDCGRMLTRMWYCS |
| Background | Glypican-3 is a protein, which is encoded by the GPC3 gene in humans.The protein core of GPC3 consists of two subunits, where the N-terminal subunit has a size of ~40 kDa and the C-terminal subunit is ~30 kDa.Glypican 3 is a potential therapeutic target for treating liver cancer and other cancers. Several therapeutic anti-GPC3 antibodies have been developed. |
Information sourced from Uniprot.org
